Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively.

This week's theme focuses on the foundations of bioelectricity including electricity in solutions.

The learning objectives for this week are:

• Explain the conflict between Galvani and Volta

• Interpret the polarity of Vm in terms of voltages inside as compared to outside cells

• Interpret the polarity of Im in terms of current flow into or out of a cell.

• Determine the energy in Joules of an ordinary battery, given its specifications.

• State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials.

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest.

The learning objectives for this week are:

- Describe the function of the sodium-potassium pump
- State from memory an approximate value for RT/F
- Be able to find the equilibrium potential from ionic concentrations and relative permeabilities
- Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall.

The learning objectives for this week are:

- Describe the passive as compared to active responses to stimulation
- Describe the opening and closing of a channel in terms of probabilities
- Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities
- Compute how the channel probabilities change when voltage Vm changes.

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow.

The learning objectives for this week are:

- Describe the purpose of each of the 4 model levels (1) alpha/beta (2)probabilities (3) ionic currents (4) trans-membrane voltage
- Estimate changes in each probability over a small interval $$\Delta t$$
- Compute the ionic current of potassium, sodium, and chloride from the state variables
- Estimate the change in trans-membrane potential over a short interval $$\Delta t$$
- State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery

This week we will examine axial and transmembrane currents within and around the tissue structure: including how these currents are determined by transmembrane voltages from site to site within the tissue, at each moment.

The learning objectives for this week are:

- Select the characteristics that distinguish core-conductor from other models.
- Identify the differences between axial and trans-membrane currents
- Given a list of trans-membrane potentials, decide where axial andtrans-menbrane currents can be found.
- Compute axial currents in multiple fiber sigments from trans-membrane potentials and fiber parameters
- Compute membrane currents at multiple sites from trans-mebrane potentials

this week we will examine how action potentials in one region normally produce action potentials in adjacent regions, so that there is a sequence of action potentials, an excitation wave. the learning objectives for this week are:

- Identify the differences between the propagation pattern following sub-threshold versus threshold stimuli
- Compute the changes in transmembrane potentials and currents from one time to a short time laterIdentify the outcome of stimulating a fiber at both ends
- Quantify the interval after propagation following one stimulus to the time when there will be another excitation wave following a 2nd stimulus
- Explain why "propagation" is different from "movement"

In Week 7, we will briefly review the course, take a quick look at the next course at the second course in the series and complete the final exam. Good luck and thank you for joining me in the course. rcb.

Dates:

- Free schedule

More on this topic:

Advanced Partial Differential Equations with Applications

The focus of the course is the concepts and techniques for solving the partial...

The focus of the course is the concepts and techniques for solving the partial...

Cell Biology

This course deals with the biology of cells of higher organisms: The structure...

This course deals with the biology of cells of higher organisms: The structure...

Understanding Einstein: The Special Theory of Relativity

This course offers you the opportunity to gain a deeper understanding of the...

This course offers you the opportunity to gain a deeper understanding of the...

Marketing Research and Analysis

This course provides a comprehensive introduction to marketing research...

This course provides a comprehensive introduction to marketing research...

More from 'Physics':

Analyzing the Universe

Using publicly available data from NASA of actual satellite observations of...

Using publicly available data from NASA of actual satellite observations of...

Astrobiology and the Search for Extraterrestrial Life

Learn about the origin and evolution of life and the search for life beyond...

Learn about the origin and evolution of life and the search for life beyond...

Confronting The Big Questions: Highlights of Modern Astronomy

An introduction to modern astronomy's most important questions. The four sections...

An introduction to modern astronomy's most important questions. The four sections...

From the Big Bang to Dark Energy

This course will cover various topics on the discoveries about how the Universe...

This course will cover various topics on the discoveries about how the Universe...

Creativity, Innovation, and Change | 创意，创新, 与 变革

Let’s make history together - again! 让我们再一次创造历史！ In 2013, over 130,000 people...

Let’s make history together - again! 让我们再一次创造历史！ In 2013, over 130,000 people...

More from 'Coursera':

First Year Teaching (Secondary Grades) - Success from the Start

Success with your students starts on Day 1. Learn from NTC's 25 years developing...

Success with your students starts on Day 1. Learn from NTC's 25 years developing...

Understanding 9/11: Why Did al Qai’da Attack America?

This course will explore the forces that led to the 9/11 attacks and the policies...

This course will explore the forces that led to the 9/11 attacks and the policies...

Aboriginal Worldviews and Education

This course will explore indigenous ways of knowing and how this knowledge can...

This course will explore indigenous ways of knowing and how this knowledge can...

Analytic Combinatorics

Analytic Combinatorics teaches a calculus that enables precise quantitative...

Analytic Combinatorics teaches a calculus that enables precise quantitative...

Accountable Talk®: Conversation that Works

Designed for teachers and learners in every setting - in school and out, in...

Designed for teachers and learners in every setting - in school and out, in...

© 2013-2019