This course provides an introduction to the genetic basis of human disease. Students begin by studying diseases that are inherited in a Mendelian fashion, such as sickle cell disease and cystic fibrosis. The idea of complex trait inheritance is then introduced through examples of diseases with more complex and mixed inheritance patterns. Students study complex genetic traits and diseases such as Type II diabetes, schizophrenia, obesity, and asthma and examine results from the recent genome-wide association studies that have expanded our understanding of human disease architecture. The course concludes with a discussion of the potential for personalized medicine as well as personal genomics.
Prerequisites: introductory biology and introductory genetics required; molecular biology strongly recommended. (4 credits)
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